Publications

circRNA related publications by the Consortium

Schreiner S, Didio A, Hung LH, Bindereif A. Design and application of circular RNAs with protein-sponge function. Nucleic Acids Res. 2020 Dec 2;48(21):12326-12335. PMID: 33231682; PMCID: PMC7708053. doi: 10.1093/nar/gkaa1085

Andreia Gomes-Duarte, Sebastian Bauer, Morten T. Venø, Braxton A. Norwood, David C. Henshall, Jørgen Kjems, Felix Rosenow, Vamshidhar R. Vangoor and R. Jeroen Pasterkamp. Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy. Front. Genet., 28 January 2021 doi.org/10.3389/fgene.2021.627907

Moldovan LI, Tsoi LC, Ranjitha U, Hager H, Weidinger S, Gudjonsson JE, Kjems J, Kristensen LS. Characterization of Circular RNA Transcriptomes in Psoriasis and Atopic Dermatitis Reveals Disease-specific Expression Profiles. Exp Dermatol. 2020 Oct 28. doi: 10.1111/exd.14227. Epub ahead of print. PMID: 33113213.

Kristensen LS, Ebbesen KK, Sokol M, Jakobsen T, Korsgaard U, Eriksen AC, Hansen TB, Kjems J, Hager H. Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory. Nat Commun. 2020 Sep 11;11(1):4551. doi: 10.1038/s41467-020-18355-2. PMID: 32917870; PMCID: PMC7486402.

Vangoor VR, Gomes-Duarte A, Pasterkamp RJ. Long non-coding RNAs in motor neuron development and disease. J Neurochem. 2020 Sep 24. doi: 10.1111/jnc.15198. Epub ahead of print. PMID: 32970857.

Pamudurti NR, Patop IL, Krishnamoorthy A, Ashwal-Fluss R, Bartok O, Kadener S. An in vivo strategy for knockdown of circular RNAs. Cell Discov. 2020 Aug 11;6:52. doi: 10.1038/s41421-020-0182-y. PMID: 32818061; PMCID: PMC7417560.

Brignani S, Raj DDA, Schmidt ERE, Düdükcü Ö, Adolfs Y, De Ruiter AA, Rybiczka-Tesulov M, Verhagen MG, van der Meer C, Broekhoven MH, Moreno-Bravo JA, Grossouw LM, Dumontier E, Cloutier JF, Chédotal A, Pasterkamp RJ. Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron. 2020 Aug 19;107(4):684-702.e9. doi: 10.1016/j.neuron.2020.05.037. Epub 2020 Jun 19. PMID: 32562661.

Di Timoteo G, Rossi F, Bozzoni I. Circular RNAs in cell differentiation and development. Development. 2020 Aug 24;147(16):dev182725. doi: 10.1242/dev.182725. PMID: 32839270.

Yoshimoto R, Rahimi K, Hansen TB, Kjems J, Mayeda A. Biosynthesis of Circular RNA ciRS-7/CDR1as Is Mediated by Mammalian-wide Interspersed Repeats. iScience. 2020 Jul 24;23(7):101345. doi: 10.1016/j.isci.2020.101345. Epub 2020 Jul 4. PMID: 32683316; PMCID: PMC7371899.

Lo I, Hill J, Vilhjálmsson BJ, Kjems J. Linking the association between circRNAs and Alzheimer’s disease progression by multi-tissue circular RNA characterization. RNA Biol. 2020 Jul 3:1-9. doi: 10.1080/15476286.2020.1783487. Epub ahead of print. PMID: 32618510.

Brignani S, Raj DDA, Schmidt ERE, Düdükcü Ö, Adolfs Y, De Ruiter AA, Rybiczka-Tesulov M, Verhagen MG, van der Meer C, Broekhoven MH, Moreno-Bravo JA, Grossouw LM, Dumontier E, Cloutier JF, Chédotal A, Pasterkamp RJ. Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development. Neuron. 2020 Jun 18:S0896-6273(20)30406-2. doi: 10.1016/j.neuron.2020.05.037.

Di Timoteo G, Dattilo D, Centrón-Broco A, Colantoni A, Guarnacci M, Rossi F, Incarnato D, Oliviero S, Fatica A, Morlando M, Bozzoni I. Modulation of circRNA Metabolism by m⁶A Modification. Cell Rep. 2020 May 12;31(6):107641. doi: 10.1016/j.celrep.2020.107641.

Das Mahapatra K, Pasquali L, Søndergaard JN, Lapins J, Nemeth IB, Baltás E, Kemény L, Homey B, Moldovan LI, Kjems J, Kutter C, Sonkoly E, Kristensen LS, Pivarcsi A. A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma. Sci Rep. 2020 Feb 27;10(1):3637. doi: 10.1038/s41598-020-59660-6.

Suenkel C, Cavalli D, Massalini S, Calegari F, Rajewsky N. A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain. Cell Rep. 2020 Feb 18;30(7):2170-2179.e5. doi: 10.1016/j.celrep.2020.01.083.

Moldovan LI, Hansen TB, Venø MT, Okholm TLH, Andersen TL, Hager H, Iversen L, Kjems J, Johansen C, Kristensen LS. High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome. BMC Med Genomics. 2019 Nov 27;12(1):174. doi:10.1186/s12920-019-0616-2

Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019 Aug 8. doi: 10.1038/s41576-019-0158-7. [Epub ahead of print] Review.

De Santis R, Alfano V, de Turris V, Colantoni A, Santini L, Garone MG, Antonacci G, Peruzzi G, Sudria-Lopez E, Wyler E, Anink JJ, Aronica E, Landthaler M, Pasterkamp RJ, Bozzoni I, Rosa A. Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis. Cell Rep. 2019 Jun 25;27(13):3818-3831.e5. doi: 10.1016/j.celrep.2019.05.085.

Patop IL, Wüst S, Kadener S. Past, present, and future of circRNAs. EMBO J. 2019 Aug 15;38(16):e100836. doi: 10.15252/embj.2018100836. Epub 2019 Jul 25. Review.

Chekulaeva M, Rajewsky N. Roles of Long Noncoding RNAs and Circular RNAs in Translation. Cold Spring Harb Perspect Biol. 2019 Jun 3;11(6):a032680. doi: 10.1101/cshperspect.a032680.

Rossi F, Legnini I, Megiorni F, Colantoni A, Santini T, Morlando M, Di Timoteo G, Dattilo D, Dominici C, Bozzoni I. Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma. Oncogene. 2019 May;38(20):3843-3854. doi: 10.1038/s41388-019-0699-4.

Voellenkle C, Perfetti A, Carrara M, Fuschi P, Renna LV, Longo M, Sain SB, Cardani R, Valaperta R, Silvestri G, Legnini I, Bozzoni I, Furling D, Gaetano C, Falcone G, Meola G, Martelli F. Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1. Int J Mol Sci. 2019 Apr 19;20(8). pii: E1938. doi: 10.3390/ijms20081938.

Hollensen AK, Andersen S, Hjorth K, Bak RO, Hansen TB, Kjems J, Aagaard L, Damgaard CK, Mikkelsen JG. Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs. Mol Ther Nucleic Acids. 2018 Dec 7;13:365-375. doi: 10.1016/j.omtn.2018.09.009.

Jost I, Shalamova LA, Gerresheim GK, Niepmann M, Bindereif A, Rossbach O. Functional sequestration of microRNA-122 from Hepatitis C Virus by circular RNA sponges. RNA Biol. 2018;15(8):1032-1039. doi: 10.1080/15476286.2018.1435248.

Preußer C, Hung LH, Schneider T, Schreiner S, Hardt M, Moebus A, Santoso S, Bindereif A. Selective release of circRNAs in platelet-derived extracellular vesicles. J Extracell Vesicles. 2018 Jan 15;7(1):1424473. doi: 10.1080/20013078.2018.1424473.

Vera Zywitza, Aristotelis Misios, Lena Bunatyan, Thomas E. Willnow, Nikolaus Rajewsky. Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis. Cell Reports 2018, doi: https://doi.org/10.1101/365619

Schneider T, Schreiner S, Preußer C, Bindereif A, Rossbach O. Northern Blot Analysis of Circular RNAs. Methods Mol Biol. 2018;1724:119-133. doi: 10.1007/978-1-4939-7562-4_10.

Patop IL, Kadener S.  circRNAs in Cancer. Curr Opin Genet Dev. 2018 Feb;48:121-127.

suggestions to read

Memczak et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature 495 (7441): 333-8 (2013)

Jeck et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA 19(2):141-57 (2013)

Hansen et al. Natural RNA circles function as efficient microRNA sponges. Nature 495(7441):384-8 (2013)

Vicens and Westhof Biogenesis of Circular RNAs. Cell. 159(1)13-4 (2014)

Ashwal-Fluss et al. circRNA biogenesis competes with pre-mRNA splicing. Mol. Cell. 56(1):55-66 (2014)

Ivanov et al. Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals. Cell Reports 10(2):170-7. (2015)

Rybak-Wolf et al. Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. Mol. Cell. 58(5):870-85 (2015)

Schneider et al. CircRNA-protein complexes: IMP3 protein component defines subfamily of circRNPs. Sci Rep. 2016 Aug 11;6:31313.

Errichelli et al. FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons. Nat Commun. 2017; 8: 14741.

Pamudurti et al. Translation of CircRNAs. Mol Cell. 2017 Apr 6;66(1):9-21.e7

Legnini et al. Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Mol Cell. 2017 Apr 6;66(1):22-37.e9.

Piwecka et al. Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science. 2017 Sep 22;357(6357).

Schneider and Bindereif Circular RNAs: Coding or noncoding? Cell Res. 2017 June;27(6):724-725.